The cheapest weekly shots
Every programme sorted on what leaves your account each month, with membership fees counted and teaser rates ignored.
Updated 2026-09-18
How we are paid: one company on this page — Coreage Rx — pays us a commission if you sign up through our link. It does not buy a better score, a higher position, or the removal of a single criticism. Our rating method and full disclosure are both public.
One number matters when you compare these: what you are charged in month two, once any introductory rate has lapsed and any membership has renewed.
On that basis the cheapest tirzepatide is Coreage Rx at $199 a month, and the cheapest semaglutide is Coreage Rx at $149. The dearest tirzepatide is Henry Meds at $449 — the same class of medication, more than twice the price.
Tirzepatide
| Programme | Per month | Dose-price | Our score |
|---|---|---|---|
| Coreage Rx Best overall on true monthly cost | $199 | Flat | 4.5 |
| Trimi Lowest flat price with named pharmacies | $125 | Varies | 4.6 |
| PlexusDx Pharmacy transparency and genetic testing | $189 | Varies | 4.4 |
| Ivím Health Unlimited clinician access | $199 | Varies | 4 |
| Mochi Health Insurance concierge support | $278 incl. $79 fee | Varies | 3.6 |
| Coby Health Multi-month value with supplies included | $239 | Varies | 3.6 |
| Hims & Hers Widest range of formats | $238 incl. $39 fee | Varies | 3.5 |
| Ro Branded medication with insurance help | $448 incl. $149 fee | Varies | 3.5 |
| Zealthy Low-cost entry with insurance routing | $216 | Varies | 3.5 |
| LifeMD Insurance coordination | $149 | Varies | 3.5 |
| Noom Med Behaviour change alongside medication | $149 | Varies | 3.5 |
| Remedy Meds Flat pricing with unlimited clinician access | $399 | Varies | 3.5 |
Semaglutide
| Programme | Per month | Dose-price | Our score |
|---|---|---|---|
| Coreage Rx Best overall on true monthly cost | $149 | Flat | 4.5 |
| Trimi Lowest flat price with named pharmacies | $99 | Varies | 4.6 |
| PlexusDx Pharmacy transparency and genetic testing | $189 | Varies | 4.4 |
| Ivím Health Unlimited clinician access | $199 | Varies | 4 |
| Mochi Health Insurance concierge support | $178 incl. $79 fee | Varies | 3.6 |
| Coby Health Multi-month value with supplies included | $229 | Varies | 3.6 |
| Hims & Hers Widest range of formats | $188 incl. $39 fee | Varies | 3.5 |
| Ro Branded medication with insurance help | $448 incl. $149 fee | Varies | 3.5 |
| Zealthy Low-cost entry with insurance routing | $151 | Varies | 3.5 |
| LifeMD Insurance coordination | $149 | Varies | 3.5 |
| Noom Med Behaviour change alongside medication | $149 | Varies | 3.5 |
| Remedy Meds Flat pricing with unlimited clinician access | $299 | Varies | 3.5 |
Two programmes we keep out of the price sort
Sorting on price only means something if every row buys the same thing. Two do not: LifeMD — the monthly charge buys clinical care and insurance work, not medication — the drug is billed separately; Noom Med — medication is included, but at deliberately low doses well below those used in the trials; WeightWatchers Clinic — the monthly charge buys clinical care and insurance work, not medication — the drug is billed separately.
Both are reviewed in full and either can be the right answer — see LifeMD and Noom.
Where the extra money hides
- A membership that renews higher than its introductory rate — this is the commonest one.
- A medication price quoted without the platform fee billed beside it.
- A fee that buys care and no medication at all.
- A cheap advertised tier that is an oral or sublingual product, not the weekly injection.
- A price that climbs each time your dose does.
- An insured price quoted at people who will be paying cash.
Cheap is not the same as right, though — if this is your first course, read best for beginners before you choose on price alone.
Brand-name prices, for comparison
Through LillyDirect self-pay, single-dose Zepbound vials at 5 mg, 7.5 mg and 10 mg have been listed at $499/month, with lower starting doses nearer $299-$349.
Through NovoCare, Wegovy has been offered at $199/month for the first two fills through 31 December 2026, then $349/month for 0.25-2.4 mg doses. The oral form is listed between $149 and $299/month by dose.
Those are the FDA-approved products. Compounded versions are not reviewed by the FDA in the same way — see is compounded still legal.
Read next
- Best programmes if this is your first time
Ranked on how they price the dose ladder and how reachable support is — the two things that decide whether a beginner stays on treatment.
- Best programmes for actual support
Most people who quit do it in the first eight weeks. Ranked on who answers when side effects arrive.
- The dose ladder
Why you start low, how fast you climb, and why the price of each rung matters more than people expect.
- Is compounded medication still legal?
Yes, but much more narrowly than in 2024. What changed, and the five questions to ask before you start.
- Coreage Rx semaglutide review
Best overall on true monthly cost. How they handle your dose ladder, what support looks like when side effects hit, and what you actually pay — $149 a month.