Practical guides
The things nobody covers properly in the welcome email.
- Your first injection
What actually happens, step by step. It is a very small needle and it goes into fat, not muscle.
Updated 2026-09-18
- The dose ladder
Why you start low, how fast you climb, and why the price of each rung matters more than people expect.
Updated 2026-09-18
- Side effects, week by week
What most people get, when it usually settles, and the signs that mean stop and call someone.
Updated 2026-09-18
- Missed doses, storage and travel
The practical questions nobody covers in the welcome email.
Updated 2026-09-18
- Tirzepatide or semaglutide?
One produced larger average weight loss in a head-to-head trial. The other is gentler on the wallet and, for some people, on the stomach.
Updated 2026-09-18
- Is compounded medication still legal?
Yes, but much more narrowly than in 2024. What changed, and the five questions to ask before you start.
Updated 2026-09-18
- How to spot a bad seller
The FDA sent more than 55 warning letters to online GLP-1 sellers in one day. Here is how to tell a licensed programme from the rest.
Updated 2026-09-18
- The twelve-month cost
Build a year-long budget from actual charges, supply periods and the terms for stopping future payments.
Updated 2026-10-15
- Medicare, GLP-1s and the $50 month
CMS is running a time-limited programme giving eligible Part D members certain GLP-1s for $50 a month. If you are on Medicare, read this before paying cash for anything.
Updated 2026-09-18
- The approved pills changed the maths
Two oral GLP-1s were approved either side of the new year, both starting at $149 a month. That undercuts a large part of the compounded market.
Updated 2026-09-18
- What happens when you stop
Most people regain a substantial share of the weight. Here is what the research actually found, and what that means for how you plan and budget.
Updated 2026-09-18
- GLP-1s after 50
These drugs work at any age. The risks are not identical at every age, and the muscle and bone question deserves more attention than it usually gets.
Updated 2026-09-18
- Titration, properly explained
When to step up, when to hold, when to go back down, and why restarting after a gap is the one genuinely dangerous mistake.
Updated 2026-09-18
- How to read your prescription
What the abbreviations mean, and the mg-versus-mL distinction that is the one genuine hazard in this category.
Updated 2026-09-18
A closer look at the research
Explore what digestive symptom findings reveal about continuing treatment, and which questions require different evidence.
- Semaglutide continuation studies: who reaches the comparison?
An explanation of entry conditions, comparator history and the evidence needed to apply a continuation result to a different treatment question.
- Tirzepatide injections: reading symptoms after a shared treatment history
A guide to defining the comparison, separating observation from treatment receipt, and judging which evidence could support a change in product or delivery.