Best for you

Best if this is your first time

Ranked on the two things that decide whether a first course succeeds: reachable clinical support and a price that does not punish you for going slowly.

Updated 2026-09-18

How we are paid: one company on this page — Coreage Rx — pays us a commission if you sign up through our link. It does not buy a better score, a higher position, or the removal of a single criticism. Our rating method and full disclosure are both public.

Most people who abandon a GLP-1 do it in the first eight weeks, and side effects are almost always why. That makes the first course a different buying decision from a renewal.

So this page filters on two things: whether you can reach a clinician when a dose goes badly, and whether you can leave without forfeiting a prepaid block. Price still counts — it is the heaviest weight in our rubric — but it is not the only thing that decides whether you are still taking this in month three.

How we decided what belongs here

Scores 3.5 or better on clinical support.
Month-to-month available — no prepaid block or fixed contract required.
Ranked on the full rubric.

12 of the 21 providers we track qualify. Prices checked 2026-09-18 and re-checked periodically.

The list

#	Provider	Per month	Per year	Score
1	Coreage Rx	$199	$2,388	4.5
2	PlexusDx	$189	$2,268	4.4
3	Ozari Health	$125	$1,500	4.4
4	Ivím Health	$199	$2,388	4
5	Mochi Health	$278	$3,336	3.6
6	Hims & Hers	$238	$2,856	3.5
7	Ro	$448	$5,376	3.5
8	LifeMD	$149	$1,788	3.5
9	Noom Med	$149	$1,788	3.5
10	Remedy Meds	$399	$4,788	3.5
11	Lemonaid Health	$348	$4,176	3.5
12	Henry Meds	$449	$5,388	3

Cheapest qualifying option: Ozari Health at $125 a month. Our featured partner is pinned to the top of the list where it qualifies — see how we rate for who scores higher.

1. Coreage Rx — Best overall on true monthly cost

$199 a month, no membership fee. Flat-rate telehealth program for compounded GLP-1s. The medication, the clinician visits and the ongoing check-ins are quoted as one number, with no separate membership billed alongside it.

The $99 and $149 rates are annual-plan prices. If you want month-to-month, budget $149 and $199 instead, and check the refund terms before prepaying a year. Read the full Coreage Rx review.

2. PlexusDx — Pharmacy transparency and genetic testing

$189 a month, no membership fee. Prescription GLP-1 and peptide programmes with no membership fee, built around genetic testing, using independent clinicians and a publicly listed set of 503A pharmacies.

The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier. Read the full PlexusDx review.

3. Ozari Health — Lowest advertised semaglutide price

$125 a month, no membership fee. Flat-rate compounded GLP-1 telehealth service operating in all 50 states, with physician review through the Arora Health network and a dedicated health concierge.

Confirm whether $86 is a month-to-month rate or requires a longer commitment, and ask which pharmacy compounds it. Read the full Ozari Health review.

Questions people ask us

How long before I notice anything?

Appetite changes often appear within the first fortnight. The starting dose is an acclimatisation dose rather than a treatment dose, so the first month or two can feel underwhelming — that is expected.

Should I commit to an annual plan to save money?

Not at the start. Get through two dose increases first, then switch if it suits you. You give up a little saving and remove most of the risk.

Before you choose on price

Compounded preparations are not FDA-approved. Two approved oral GLP-1s now start around $149 a month, and from 1 July 2026 eligible Medicare beneficiaries can access certain GLP-1s for $50 a month — both of which beat a large part of this market. See the approved pills and the Medicare programme.

In SURMOUNT-1, adults with obesity lost an average of 19.5% of body weight on 10 mg and 20.9% on 15 mg over 72 weeks. That figure comes from a controlled trial of the active ingredient, not from any particular seller's product.