Best if this is your first time

Most people who abandon a GLP-1 do it in the first eight weeks, and side effects are almost always why. That makes the first course a different buying decision from a renewal.

So this page filters on two things: whether you can reach a clinician when a dose goes badly, and whether you can leave without forfeiting a prepaid block. Price still counts — it is the heaviest weight in our rubric — but it is not the only thing that decides whether you are still taking this in month three.

How we decided what belongs here

• Scores 3.5 or better on clinical support.
• Month-to-month available — no prepaid block or fixed contract required.
• Ranked on the full rubric.

12 of the 23 providers we track qualify. Prices checked 2026-09-18 and re-checked periodically.

Questions people ask us

How long before I notice anything?

Appetite changes often appear within the first fortnight. The starting dose is an acclimatisation dose rather than a treatment dose, so the first month or two can feel underwhelming — that is expected.

Should I commit to an annual plan to save money?

Not at the start. Get through two dose increases first, then switch if it suits you. You give up a little saving and remove most of the risk.

Before you choose on price

Worth knowing before you start: the approved oral options avoid injections entirely and start around $149, and if you are on Medicare the $50 programme begins in July 2026.

In SURMOUNT-1, adults with obesity lost an average of 19.5% of body weight on 10 mg and 20.9% on 15 mg over 72 weeks. That figure comes from a controlled trial of the active ingredient, not from any particular seller's product.