Semaglutide 0.25 mg: what it costs
Step 1 of the semaglutide ladder, around weeks 1-4. 6 providers charge the same here as at the starting dose — the rest may not.
Updated 2026-09-18
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0.25 mg is step 1 of 5 on the semaglutide ladder, reached around weeks 1-4. A starting dose, not a treatment dose. Its entire job is to let your body get used to the drug.
Because this is an early rung, the main cost question is not what 0.25 mg costs today but what happens when you reach the higher doses. Programmes that hold one price across the whole ladder are the ones that make that predictable.
What 0.25 mg is for
0.25 mg of semaglutide is the gentlest entry point in this whole category, which is part of why semaglutide is often chosen by people who have had a bad time on something else. It is a four-week acclimatisation dose and nothing more. If this rung is genuinely difficult, that is important information to give your prescriber before stepping up, because the steps get bigger from here.
Often uneventful. If this dose is difficult, tell your prescriber before stepping up rather than pushing through.
Where 0.25 mg sits on the ladder
| Step | Dose | Roughly when |
|---|---|---|
| 1 | 0.25 mg ← this page | weeks 1-4 |
| 2 | 0.5 mg | weeks 5-8 |
| 3 | 1 mg | weeks 9-12 |
| 4 | 1.7 mg | weeks 13-16 |
| 5 | 2.4 mg | weeks 17+ |
What 0.25 mg costs
6 of the providers we track hold a single price at every dose, so 0.25 mg costs the same as the starting dose. They are listed first below because at this rung that is the whole ballgame.
| Provider | Price at 0.25 mg | Per year | Score |
|---|---|---|---|
| Coreage Rx | $149 | $1,788 | 4.5 |
| Trimi | $99 | $1,188 | 4.6 |
| Mochi Health | $178 | $2,136 | 3.6 |
| PlexusDx | $189 | $2,268 | 4.4 |
| Eden | $198 | $2,376 | 3.1 |
| Remedy Meds | $299 | $3,588 | 3.5 |
Cheapest flat-rate option at 0.25 mg: Trimi at $99 a month, which is what it charges at every other rung too.
The remaining 8 providers either price by dose or do not publish a flat-rate commitment. Their quoted figures start at $86 a month, but that is the starting-dose price — ask specifically what 0.25 mg will cost before you assume it holds.
Worth knowing. The question to ask before you start. "What will I be charged when I reach 0.25 mg?" If the answer is not the same number you were quoted at the start, you are on a tiered programme and should budget for the higher figure rather than the advertised one.
Do you need to go higher than 0.25 mg?
Not necessarily. The ladder exists so that you can stop where the medication is working for you, and plenty of people settle below the maximum. Reaching the top dose is not a measure of success, and the trial figures are averages rather than targets.
Is 0.25 mg enough to lose weight?
It is not intended to be. It exists to let your body adapt. The weight-management evidence for semaglutide comes from 2.4 mg, four rungs further up.
Compounded preparations are not FDA-approved, and approved oral GLP-1s now start around $149 — see the approved pills. Dosing belongs to your prescriber, not this page.
Read next
- Flat pricing at every dose
Programmes where the price does not rise as your dose does — which matters more over a year than most advertised discounts.
- Semaglutide 0.5 mg: what it costs
Step 2 of the semaglutide ladder, around weeks 5-8. 6 providers charge the same here as at the starting dose — the rest may not.
- Semaglutide 1 mg: what it costs
Step 3 of the semaglutide ladder, around weeks 9-12. 6 providers charge the same here as at the starting dose — the rest may not.
- Medicare, GLP-1s and the $50 month
CMS is running a time-limited programme giving eligible Part D members certain GLP-1s for $50 a month. If you are on Medicare, read this before paying cash for anything.