Fifty 410 vs PlexusDx
$133/mo against $189/mo for tirzepatide. Which is worth it, and for whom.
Updated 2026-09-18
How we are paid: one company on this page — Coreage Rx — pays us a commission if you sign up through our link. It does not buy a better score, a higher position, or the removal of a single criticism. Our rating method and full disclosure are both public.
Both sell tirzepatide. Fifty 410 costs $133 a month and PlexusDx costs $189, a difference of $56 a month or about $672 a year. The other differences matter more than the money if this is your first course.
Fifty 410 is prepaid blocks with no subscription. PlexusDx is pharmacy transparency and genetic testing. They are not aimed at the same person, and the cheaper one is not automatically the right answer — particularly if this is your first course and you expect a slow titration.
What this means for your titration. PlexusDx holds one price at every dose and Fifty 410 does not — so this gap widens as you titrate toward a therapeutic dose, exactly when you can least afford a surprise.
Side by side
| Fifty 410 | PlexusDx | |
|---|---|---|
| Advertised from | $133 | $129 |
| Membership on top | None | None |
| True monthly cost | $133 | $189 |
| Roughly, per year | $1,596 | $2,268 |
| Price includes medication | Yes | Yes |
| Names its pharmacy | Not published | Yes |
| Our score | 4.2 / 5 | 4.4 / 5 |
Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.
The differences that affect treatment
They differ on 4 of the 7 things we track, and behave the same on the other 3. The differences are what the price gap is actually buying.
| Fifty 410 | PlexusDx | |
|---|---|---|
| Price is the same at every dose | No | Yes |
| Month-to-month without prepaying a block | No | Yes |
| Names the compounding pharmacy publicly | No | Yes |
| Offers an oral or sublingual option | No | Yes |
What each programme publishes: Fifty 410
- Compounded tirzepatide starter protocol at $133/month, sold as a $399 three-month block.
- High-dose tirzepatide protocol at $183/month, sold as a $549 three-month block.
- No membership, no subscription and no recurring charges — you buy a block outright.
- Provider consultation and free 1-2 day shipping included in the price.
- States it is a telehealth platform that does not compound or distribute medication itself, and that preparations come from FDA-registered 503A pharmacies.
- Publishes unusually detailed information on 503A standards, USP 797 sterility and batch testing.
- No payment taken unless a provider approves you.
Where it wins: Genuinely no subscription — you buy a block and nothing recurs. Watch for: The $133 is the starter protocol. Moving to the high-dose protocol takes it to $183/month, and both are prepaid three-month commitments.
What each programme publishes: PlexusDx
- GLP-1 weight-loss programmes start at $129/month.
- Compounded semaglutide injection listed at $189/month with no membership fee and the same price at every dose.
- A $189/month microdose tier is offered for compounded semaglutide or tirzepatide.
- No membership or platform fee is charged alongside the medication.
- Publicly names six 503A pharmacy partners: Belmar, Strive, Epiq Scripts, Casa Pharma Rx, The Pharmacy Hub and Foothills.
- Clinical oversight via LionMD, with named physicians and NPI numbers published.
- Licensed providers in all 50 states; CLIA-certified labs for its testing line.
Where it wins: The most detailed pharmacy disclosure in this comparison — six named 503A partners. Watch for: The advertised "from $129" is the programme floor. Budget $189/month for the compounded injection tier.
Strengths of each
Fifty 410.
- Genuinely no subscription — you buy a block and nothing recurs.
- Among the lowest tirzepatide rates verified.
- Unusually detailed public explanation of 503A standards and batch testing.
PlexusDx.
- The most detailed pharmacy disclosure in this comparison — six named 503A partners.
- Names its prescribing physicians along with their NPI numbers.
- No membership fee, and flat pricing across the dose range.
How they score
| What we weigh | Weight | Fifty 410 | PlexusDx |
|---|---|---|---|
| True monthly cost | 30% | 4.8 | 4.6 |
| Price honesty | 20% | 4.6 | 4.5 |
| Clinical support | 20% | 3.5 | 3.8 |
| Pharmacy sourcing | 15% | 4.2 | 4.9 |
| Cancelling | 15% | 3.3 | 4 |
PlexusDx scores higher overall at 4.4 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.
Which suits you
- Pick Fifty 410 if cost is the binding constraint. Over a year the gap is about $672, which is real money for the same class of medication.
- Pick PlexusDx if what it does better matters to you — the most detailed pharmacy disclosure in this comparison — six named 503a partners.
- If sourcing matters, note that PlexusDx publishes which pharmacy compounds its medication and Fifty 410 does not.
The verdict
For most people starting out, Fifty 410 at $133 a month is the more defensible choice on arithmetic alone. PlexusDx earns its premium only if you will actually use what it does differently. Read the full reviews before deciding: Fifty 410 and PlexusDx.
How they sit against everyone else
| Programme | Per month | Dose-price | Our score |
|---|---|---|---|
| Coreage Rx Best overall on true monthly cost | $199 | Flat | 4.5 |
| Trimi Lowest flat price with named pharmacies | $125 | Varies | 4.6 |
| PlexusDx Pharmacy transparency and genetic testing | $189 | Varies | 4.4 |
| Ozari Health Lowest advertised semaglutide price | $125 | Varies | 4.4 |
| Fifty 410 Prepaid blocks with no subscription | $133 | Varies | 4.2 |
| Ivím Health Unlimited clinician access | $199 | Varies | 4 |
| Mochi Health Insurance concierge support | $278 incl. $79 fee | Varies | 3.6 |
| Coby Health Multi-month value with supplies included | $239 | Varies | 3.6 |
| Hims & Hers Widest range of formats | $238 incl. $39 fee | Varies | 3.5 |
| Ro Branded medication with insurance help | $448 incl. $149 fee | Varies | 3.5 |
| Zealthy Low-cost entry with insurance routing | $216 | Varies | 3.5 |
| LifeMD Insurance coordination | $149 | Varies | 3.5 |
Read next
- Fifty 410 tirzepatide review
Prepaid blocks with no subscription. How they handle your dose ladder, what support looks like when side effects hit, and what you actually pay — $133 a month.
- PlexusDx tirzepatide review
Pharmacy transparency and genetic testing. How they handle your dose ladder, what support looks like when side effects hit, and what you actually pay — $189 a month.
- How to spot a bad seller
The FDA sent more than 55 warning letters to online GLP-1 sellers in one day. Here is how to tell a licensed programme from the rest.
- The twelve-month cost
Month one is the cheapest month you will have. Here is the full-year arithmetic, including the costs nobody puts in the advert.
- Best programmes if this is your first time
Ranked on how they price the dose ladder and how reachable support is — the two things that decide whether a beginner stays on treatment.