Fifty 410 vs Hims & Hers

Both sell tirzepatide. Fifty 410 costs $133 a month and Hims & Hers costs $238, a difference of $105 a month or about $1,260 a year. The other differences matter more than the money if this is your first course.

Fifty 410 is prepaid blocks with no subscription. Hims & Hers is widest range of formats. They are not aimed at the same person, and the cheaper one is not automatically the right answer — particularly if this is your first course and you expect a slow titration.

What this means for your titration. Both price the same way as your dose climbs, so the gap between them stays constant the whole way up the ladder.

Side by side

Prices verified 2026-09-18. "True monthly cost" is what you are billed in month two, once any introductory rate has lapsed and any membership has renewed.

The differences that affect treatment

3 of these affect how treatment actually goes. The rest are administrative.

What each programme publishes: Fifty 410

• Compounded tirzepatide starter protocol at $133/month, sold as a $399 three-month block.
• States it is a telehealth platform that does not compound or distribute medication itself, and that preparations come from FDA-registered 503A pharmacies.
• Publishes unusually detailed information on 503A standards, USP 797 sterility and batch testing.

Where it wins: Genuinely no subscription — you buy a block and nothing recurs. Watch for: The $133 is the starter protocol. Moving to the high-dose protocol takes it to $183/month, and both are prepaid three-month commitments.

What each programme publishes: Hims & Hers

• Weight-loss membership advertised at $39 for the first month.
• Company has announced oral semaglutide pricing starting around $49/month, with the 1.5 mg dose around $149/month.

Where it wins: One account covers oral, compounded injectable and branded options. Watch for: The advertised entry prices and the membership are separate charges. Add $39/month to whatever medication figure you were quoted.

Strengths of each

Fifty 410.

• Genuinely no subscription — you buy a block and nothing recurs.
• Among the lowest tirzepatide rates verified.
• Unusually detailed public explanation of 503A standards and batch testing.

Hims & Hers.

• One account covers oral, compounded injectable and branded options.
• Large enough to keep supply steady when smaller sellers run dry.
• Branded Zepbound is available without leaving the platform.

Fifty 410 scores higher overall at 4.2 out of 5. The weights are published on how we rate, and so is the note about which of these is our paid featured partner.

Which suits you

If this is your first course, weight the two rows about dose pricing above everything else. A programme that keeps the price flat lets you stop climbing when your body says so, and that single freedom does more for whether you are still taking this in month three than $105 a month does.

The verdict

For most people starting out, Fifty 410 at $133 a month is the more defensible choice on arithmetic alone. Hims & Hers earns its premium only if you will actually use what it does differently. Read the full reviews before deciding: Fifty 410 and Hims & Hers.

How they sit against everyone else